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plasma adamts13 levels  (R&D Systems)


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    Structured Review

    R&D Systems plasma adamts13 levels
    (A) Volcano plots of DEGs (PA-ILI group vs. control group). (B) Heatmap of the top 250 genes between PA-ILI mice (groups P1 & P2) and controls (groups C1 & C2). (C) Dot plots of seven GO biological process categories, including wound healing, hemostasis, coagulation, and platelet-related pathways. (D) Cnetplot displaying 57 DEGs assigned to the seven GO biological process categories. (E) Protein–protein interaction data of VWF from STRING, containing 11 nodes and 104 edges. (F) Venn diagram of 57 DEGs (red) and 11 VWF-related genes (blue) with three shared genes in the overlapping regions, including <t>ADAMTS13.</t> PA-ILI, pyrrolizidine alkaloids-induced liver injury; VWF, von Willebrand factor; DEG, differentially expressed genes; GO, Gene Ontology; STRING, Search Tool for the Retrieval of Interacting Genes/Proteins.
    Plasma Adamts13 Levels, supplied by R&D Systems, used in various techniques. Bioz Stars score: 93/100, based on 12 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/plasma+adamts13+levels/pmc11712092-57-0-13?v=R%26D+Systems
    Average 93 stars, based on 12 article reviews
    plasma adamts13 levels - by Bioz Stars, 2026-07
    93/100 stars

    Images

    1) Product Images from "ADAMTS13 Improves Hepatic Platelet Accumulation in Pyrrolizidine Alkaloids-induced Liver Injury"

    Article Title: ADAMTS13 Improves Hepatic Platelet Accumulation in Pyrrolizidine Alkaloids-induced Liver Injury

    Journal: Journal of Clinical and Translational Hepatology

    doi: 10.14218/JCTH.2024.00233

    (A) Volcano plots of DEGs (PA-ILI group vs. control group). (B) Heatmap of the top 250 genes between PA-ILI mice (groups P1 & P2) and controls (groups C1 & C2). (C) Dot plots of seven GO biological process categories, including wound healing, hemostasis, coagulation, and platelet-related pathways. (D) Cnetplot displaying 57 DEGs assigned to the seven GO biological process categories. (E) Protein–protein interaction data of VWF from STRING, containing 11 nodes and 104 edges. (F) Venn diagram of 57 DEGs (red) and 11 VWF-related genes (blue) with three shared genes in the overlapping regions, including ADAMTS13. PA-ILI, pyrrolizidine alkaloids-induced liver injury; VWF, von Willebrand factor; DEG, differentially expressed genes; GO, Gene Ontology; STRING, Search Tool for the Retrieval of Interacting Genes/Proteins.
    Figure Legend Snippet: (A) Volcano plots of DEGs (PA-ILI group vs. control group). (B) Heatmap of the top 250 genes between PA-ILI mice (groups P1 & P2) and controls (groups C1 & C2). (C) Dot plots of seven GO biological process categories, including wound healing, hemostasis, coagulation, and platelet-related pathways. (D) Cnetplot displaying 57 DEGs assigned to the seven GO biological process categories. (E) Protein–protein interaction data of VWF from STRING, containing 11 nodes and 104 edges. (F) Venn diagram of 57 DEGs (red) and 11 VWF-related genes (blue) with three shared genes in the overlapping regions, including ADAMTS13. PA-ILI, pyrrolizidine alkaloids-induced liver injury; VWF, von Willebrand factor; DEG, differentially expressed genes; GO, Gene Ontology; STRING, Search Tool for the Retrieval of Interacting Genes/Proteins.

    Techniques Used: Control, Coagulation

    (A) Representative images (left) and quantification (right) of hepatic ADAMTS13 (red) in patients (n = 3). (B) Plasma level of ADAMTS13 in patients (leftmost). Peripheral platelet count and plasma ADAMTS13 concentration in mild and severe PA-ILI (middle). Relationship between peripheral platelet count and plasma ADAMTS13 in PA-ILI patients (rightmost). (C) Representative Western blots of ADAMTS13 in mouse plasma, lungs, and kidneys. (D) Hepatic mRNA level of ADAMTS13 in MCT-treated mice. (E) Representative Western blots of ADAMTS13 and apoptosis-related proteins. (F) Representative images (left) and quantification (right) of hepatic ADAMTS13 (red) in the mouse liver (n = 3). * p < 0.05, ** p < 0.01, **** p < 0.0001. PA-ILI, pyrrolizidine alkaloids-induced liver injury; DAPI, 4′,6-diamidino-2-phenylindole; MCT, monocrotaline.
    Figure Legend Snippet: (A) Representative images (left) and quantification (right) of hepatic ADAMTS13 (red) in patients (n = 3). (B) Plasma level of ADAMTS13 in patients (leftmost). Peripheral platelet count and plasma ADAMTS13 concentration in mild and severe PA-ILI (middle). Relationship between peripheral platelet count and plasma ADAMTS13 in PA-ILI patients (rightmost). (C) Representative Western blots of ADAMTS13 in mouse plasma, lungs, and kidneys. (D) Hepatic mRNA level of ADAMTS13 in MCT-treated mice. (E) Representative Western blots of ADAMTS13 and apoptosis-related proteins. (F) Representative images (left) and quantification (right) of hepatic ADAMTS13 (red) in the mouse liver (n = 3). * p < 0.05, ** p < 0.01, **** p < 0.0001. PA-ILI, pyrrolizidine alkaloids-induced liver injury; DAPI, 4′,6-diamidino-2-phenylindole; MCT, monocrotaline.

    Techniques Used: Clinical Proteomics, Concentration Assay, Western Blot

    (A) Representative Western blots and quantification of plasma and hepatic ADAMTS13 protein. (B) Pathological changes in PA-ILI mice treated with rADAMTS13. (C) Measurement of hepatic necrosis (n = 5). (D) Representative images (left) and quantification (right) of hepatic platelets (CD41, red) and VWF deposition (green). * p < 0.05, ** p < 0.01, *** p < 0.001. PA-ILI, pyrrolizidine alkaloids-induced liver injury; VWF, von Willebrand factor; DAPI, 4′,6-diamidino-2-phenylindole; MCT, monocrotaline.
    Figure Legend Snippet: (A) Representative Western blots and quantification of plasma and hepatic ADAMTS13 protein. (B) Pathological changes in PA-ILI mice treated with rADAMTS13. (C) Measurement of hepatic necrosis (n = 5). (D) Representative images (left) and quantification (right) of hepatic platelets (CD41, red) and VWF deposition (green). * p < 0.05, ** p < 0.01, *** p < 0.001. PA-ILI, pyrrolizidine alkaloids-induced liver injury; VWF, von Willebrand factor; DAPI, 4′,6-diamidino-2-phenylindole; MCT, monocrotaline.

    Techniques Used: Western Blot, Clinical Proteomics



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    (A) Volcano plots of DEGs (PA-ILI group vs. control group). (B) Heatmap of the top 250 genes between PA-ILI mice (groups P1 & P2) and controls (groups C1 & C2). (C) Dot plots of seven GO biological process categories, including wound healing, hemostasis, coagulation, and platelet-related pathways. (D) Cnetplot displaying 57 DEGs assigned to the seven GO biological process categories. (E) Protein–protein interaction data of VWF from STRING, containing 11 nodes and 104 edges. (F) Venn diagram of 57 DEGs (red) and 11 VWF-related genes (blue) with three shared genes in the overlapping regions, including <t>ADAMTS13.</t> PA-ILI, pyrrolizidine alkaloids-induced liver injury; VWF, von Willebrand factor; DEG, differentially expressed genes; GO, Gene Ontology; STRING, Search Tool for the Retrieval of Interacting Genes/Proteins.
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    (A) Volcano plots of DEGs (PA-ILI group vs. control group). (B) Heatmap of the top 250 genes between PA-ILI mice (groups P1 & P2) and controls (groups C1 & C2). (C) Dot plots of seven GO biological process categories, including wound healing, hemostasis, coagulation, and platelet-related pathways. (D) Cnetplot displaying 57 DEGs assigned to the seven GO biological process categories. (E) Protein–protein interaction data of VWF from STRING, containing 11 nodes and 104 edges. (F) Venn diagram of 57 DEGs (red) and 11 VWF-related genes (blue) with three shared genes in the overlapping regions, including <t>ADAMTS13.</t> PA-ILI, pyrrolizidine alkaloids-induced liver injury; VWF, von Willebrand factor; DEG, differentially expressed genes; GO, Gene Ontology; STRING, Search Tool for the Retrieval of Interacting Genes/Proteins.
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    Image Search Results


    (A) Volcano plots of DEGs (PA-ILI group vs. control group). (B) Heatmap of the top 250 genes between PA-ILI mice (groups P1 & P2) and controls (groups C1 & C2). (C) Dot plots of seven GO biological process categories, including wound healing, hemostasis, coagulation, and platelet-related pathways. (D) Cnetplot displaying 57 DEGs assigned to the seven GO biological process categories. (E) Protein–protein interaction data of VWF from STRING, containing 11 nodes and 104 edges. (F) Venn diagram of 57 DEGs (red) and 11 VWF-related genes (blue) with three shared genes in the overlapping regions, including ADAMTS13. PA-ILI, pyrrolizidine alkaloids-induced liver injury; VWF, von Willebrand factor; DEG, differentially expressed genes; GO, Gene Ontology; STRING, Search Tool for the Retrieval of Interacting Genes/Proteins.

    Journal: Journal of Clinical and Translational Hepatology

    Article Title: ADAMTS13 Improves Hepatic Platelet Accumulation in Pyrrolizidine Alkaloids-induced Liver Injury

    doi: 10.14218/JCTH.2024.00233

    Figure Lengend Snippet: (A) Volcano plots of DEGs (PA-ILI group vs. control group). (B) Heatmap of the top 250 genes between PA-ILI mice (groups P1 & P2) and controls (groups C1 & C2). (C) Dot plots of seven GO biological process categories, including wound healing, hemostasis, coagulation, and platelet-related pathways. (D) Cnetplot displaying 57 DEGs assigned to the seven GO biological process categories. (E) Protein–protein interaction data of VWF from STRING, containing 11 nodes and 104 edges. (F) Venn diagram of 57 DEGs (red) and 11 VWF-related genes (blue) with three shared genes in the overlapping regions, including ADAMTS13. PA-ILI, pyrrolizidine alkaloids-induced liver injury; VWF, von Willebrand factor; DEG, differentially expressed genes; GO, Gene Ontology; STRING, Search Tool for the Retrieval of Interacting Genes/Proteins.

    Article Snippet: Plasma ADAMTS13 levels were measured using a Human ADAMTS13 Quantikine ELISA kit (DADT130; R&D Systems, Minneapolis, MN, USA) per the manufacturer’s instructions.

    Techniques: Control, Coagulation

    (A) Representative images (left) and quantification (right) of hepatic ADAMTS13 (red) in patients (n = 3). (B) Plasma level of ADAMTS13 in patients (leftmost). Peripheral platelet count and plasma ADAMTS13 concentration in mild and severe PA-ILI (middle). Relationship between peripheral platelet count and plasma ADAMTS13 in PA-ILI patients (rightmost). (C) Representative Western blots of ADAMTS13 in mouse plasma, lungs, and kidneys. (D) Hepatic mRNA level of ADAMTS13 in MCT-treated mice. (E) Representative Western blots of ADAMTS13 and apoptosis-related proteins. (F) Representative images (left) and quantification (right) of hepatic ADAMTS13 (red) in the mouse liver (n = 3). * p < 0.05, ** p < 0.01, **** p < 0.0001. PA-ILI, pyrrolizidine alkaloids-induced liver injury; DAPI, 4′,6-diamidino-2-phenylindole; MCT, monocrotaline.

    Journal: Journal of Clinical and Translational Hepatology

    Article Title: ADAMTS13 Improves Hepatic Platelet Accumulation in Pyrrolizidine Alkaloids-induced Liver Injury

    doi: 10.14218/JCTH.2024.00233

    Figure Lengend Snippet: (A) Representative images (left) and quantification (right) of hepatic ADAMTS13 (red) in patients (n = 3). (B) Plasma level of ADAMTS13 in patients (leftmost). Peripheral platelet count and plasma ADAMTS13 concentration in mild and severe PA-ILI (middle). Relationship between peripheral platelet count and plasma ADAMTS13 in PA-ILI patients (rightmost). (C) Representative Western blots of ADAMTS13 in mouse plasma, lungs, and kidneys. (D) Hepatic mRNA level of ADAMTS13 in MCT-treated mice. (E) Representative Western blots of ADAMTS13 and apoptosis-related proteins. (F) Representative images (left) and quantification (right) of hepatic ADAMTS13 (red) in the mouse liver (n = 3). * p < 0.05, ** p < 0.01, **** p < 0.0001. PA-ILI, pyrrolizidine alkaloids-induced liver injury; DAPI, 4′,6-diamidino-2-phenylindole; MCT, monocrotaline.

    Article Snippet: Plasma ADAMTS13 levels were measured using a Human ADAMTS13 Quantikine ELISA kit (DADT130; R&D Systems, Minneapolis, MN, USA) per the manufacturer’s instructions.

    Techniques: Clinical Proteomics, Concentration Assay, Western Blot

    (A) Representative Western blots and quantification of plasma and hepatic ADAMTS13 protein. (B) Pathological changes in PA-ILI mice treated with rADAMTS13. (C) Measurement of hepatic necrosis (n = 5). (D) Representative images (left) and quantification (right) of hepatic platelets (CD41, red) and VWF deposition (green). * p < 0.05, ** p < 0.01, *** p < 0.001. PA-ILI, pyrrolizidine alkaloids-induced liver injury; VWF, von Willebrand factor; DAPI, 4′,6-diamidino-2-phenylindole; MCT, monocrotaline.

    Journal: Journal of Clinical and Translational Hepatology

    Article Title: ADAMTS13 Improves Hepatic Platelet Accumulation in Pyrrolizidine Alkaloids-induced Liver Injury

    doi: 10.14218/JCTH.2024.00233

    Figure Lengend Snippet: (A) Representative Western blots and quantification of plasma and hepatic ADAMTS13 protein. (B) Pathological changes in PA-ILI mice treated with rADAMTS13. (C) Measurement of hepatic necrosis (n = 5). (D) Representative images (left) and quantification (right) of hepatic platelets (CD41, red) and VWF deposition (green). * p < 0.05, ** p < 0.01, *** p < 0.001. PA-ILI, pyrrolizidine alkaloids-induced liver injury; VWF, von Willebrand factor; DAPI, 4′,6-diamidino-2-phenylindole; MCT, monocrotaline.

    Article Snippet: Plasma ADAMTS13 levels were measured using a Human ADAMTS13 Quantikine ELISA kit (DADT130; R&D Systems, Minneapolis, MN, USA) per the manufacturer’s instructions.

    Techniques: Western Blot, Clinical Proteomics